London, June 19: Opening the door to precision medicine for prostate cancer, researchers have developed a three-in-one blood test that could tell which men would benefit from a class of new drugs, detect early signs of resistance and monitor cancer's evolution over time.
The test could be used to know within a month or two whether the drug is working on a patient. It could help to extend or save lives, by targetting treatment more effectively, while also reducing the side-effects of treatment and ensuring patients do not receive drugs that are unlikely to do them any good.
"Not only could the test have a major impact on treatment of prostate cancer, but it could also be adapted to open up the possibility of precision medicine to patients with other types of cancer as well," said Johann de Bono, Professor at The Institute of Cancer Research, London.
By testing cancer DNA in the bloodstream, researchers found they could pick out which men with advanced prostate cancer were likely to benefit from treatment with a class of new drugs called PARP inhibitors.
They also used the test to analyse DNA in the blood after treatment had started, so people who were not responding could be identified and switched to alternative therapy in as little as four to eight weeks.
And finally, they used the test to monitor a patient's blood throughout treatment, quickly picking up signs that the cancer was evolving genetically and might be becoming resistant to the drugs.
It is the first test developed for a precision prostate cancer therapy targeted at specific genetic faults within tumours, according to the researchers.
It could in future allow the PARP inhibitor olaparib to become a standard treatment for advanced prostate cancer, by targeting the drug at the men most likely to benefit.
The study, published in the journal Cancer Discovery, also identified which genetic mutations prostate cancers use to resist treatment with olaparib.
"Our study identifies, for the first time, genetic changes that allow prostate cancer cells to become resistant to the precision medicine olaparib," de Bono said.
"From these findings, we were able to develop a powerful, three-in-one test that could in future be used to help doctors select treatment, check whether it is working and monitor the cancer in the longer term. We think it could be used to make clinical decisions about whether a PARP inhibitor is working within as little as four to eight weeks of starting therapy," de Bono added.
Hyderabad, May 20: Tollywood bubbly Actress Raashi Khanna has launched the first song of the film Jambalakidi Pamba, which features Srinivas Reddy and. The actress said the song is really nice to ..Written by : IANS | 05:55 PM
Hyderabad, May 19: Hyderabad Metro Rail (HMR) will become the first metro in the country to provide Electric Vehicle (EV) Charging Stations. HMR keen to a step forward to create amazing achievemen ..Written by : IANS | 04:31 PM
Hyderabad, May 20: Tollywood Macho Star Manchu Manoj has celebrated his birthday on today, in this many of the celebrities has been wished the Young actor on thier Micro Biological sites. His fathe ..Written by : IANS | 03:53 PM
Hyderabad, April 12: Nagarjuna's song "Ninnu Roddu Meeda Chusnadi Laggayithu" one of the most popular songs in 1990's. The Song has got a tremendous response in that time. The SOng was super hit film ..Written by : IANS | 05:04 PM
Hyderabad, Apr 10: Preparations related to NTR Rama Rao biopic are ongoing. Bala Krishna is playing the role of NT Rama Rao while the rest of the cast has to be finalized. The selection process for th ..Written by : IANS | 02:13 PM
Hyderabad, Apr 03: Power star Pawan Kalyan has congratulated on the hit of Rangasthalam team here on today. Pawan spoke to Charan after watching "Rangasthalam" on the special screen, he told that h ..Written by : IANS | 04:47 PM
Hyderabad, Mar 26: The Tollywood Gorgeous actress Anushka Shetty had a fabulous start to 2018 with the solid success of Bhaagamathie. Although there have been several rumors on her future projects ..Written by : IANS | 03:04 PM
Chennai, May 20: Actor-turned-politician Raji ..
New Delhi, May 20: The public sector BSNL wil ..
Bangalore, May 20: Ending the long-lived high ..
New Delhi, May 19: Congress President Rahul G ..
Bengaluru, May 18: In a shocking comment, Mah ..
Bangalore, May 19: Just two days after taking ..
Bengaluru, May 19: BS Yeddyurappa's tenure as ..
Bengaluru, May 19: The floor test in the Karn ..
Bangalore, May 19: I cannot forget the love a ..
Bengaluru, May 19: Congress MLAs Anand Singh ..
Washington, May 18: US President Donald Trump ..
Washington, May 18: Trump who is know for his ..
New Delhi, May 17: In a major development tow ..
New Delhi, May 16: Facebook took moderation a ..
London, May 15: Chinese mobile maker Honor on ..
San Francisco, May 13: After reports surfaced ..
Beijing, May 13: As it prepares to file an in ..
Dhaka, May 12: Bangladesh launched its first ..
Kathmandu, May 12: Indian Prime Minister Nare ..
San Francisco, May 12: The giant Social media ..
New Delhi, May 20: Mahendra Singh Dhoni enjoy ..
Hyderabad, May 18: The Telangana government h ..
New Delhi, May 18: The International Cricket ..
Barcelona, May 16: FC Barcelona's star player ..
New Delhi, May 16: Continuing its Dominant sh ..
New Delhi, May 15: Plea by former cricketer S ..
Chennai, May 15: Mahendra Singh Dhoni is soon ..
Reykyavik, May 13: FIFA World Cup debutant Ic ..
New Delhi, May 09: As we knew that, The BCCI ..
New Delhi, May 09: The BCCI selectors met in ..
Hyderabad, May 20: Nowadays, Wearing a trendy ..
Hyderabad, May 19: Bharti Airtel is now offer ..
Some healthy facts of daily walk~ 1- Daily ..
New Delhi, May 16: Today, many people are una ..
New Delhi, May 15: Realme is a new brand ente ..
Mumbai, May 14: India Biggest Telecom Operato ..
Hyderabad, May 07: If you own a smartphone, t ..
Hyderabad, May 6: Weight loss is one of the l ..
Hyderabad, May 06: Losing Belly fat is not as ..
Hyderabad, April 30: Good news for the Indian ..